Gauthier S, Ng KP, Pascoal TA, Mathotaarachchi S, Chung CO, Benedetti AL, Shin M, Kang MS, Li X, Ba M, Kandiah N, Rosa-Neto P. Author response: Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017 Oct 31;89(18):1931. PubMed.

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    • User Profile Image Edward Blonz
      University of California, San Francisco
    • Posted:

    Reports of neuropsychiatric symptoms correlating with hypometabolism in preclinical AD patients are consistent with the recently proposed neuroenergetic hypothesis (Blonz 2017), and provide further correlative evidence that the process may indeed be identified before any onset of cognitive symptoms. It will be of critical importance to determine if alternate sources of metabolizable energy can moderate neuropsychiatric symptoms in the various clinical stages. 

    References:

    Blonz ER. Alzheimer's Disease as the Product of a Progressive Energy Deficiency Syndrome in the Central Nervous System: The Neuroenergetic Hypothesis. J Alzheimers Dis. 2017;60(4):1223-1229. PubMed.

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