Olsson B, Portelius E, Cullen NC, Sandelius Å, Zetterberg H, Andreasson U, Höglund K, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk D, McCluskey L, Elman L, Shaw LM, Toledo JB, McBride J, Hernandez-Con P, Lee VM, Trojanowski JQ, Blennow K. Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders. JAMA Neurol. 2018 Dec 3; PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ42
(CSF)		 AD
(397)		 136 ± 47
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 McKhann et al., 2011; McKhann et al., 1984
Aβ42
(CSF)		 PD
(41)		 262 ± 63
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 Hughes et al., 1992
NFL
(CSF)		 AD
(397)		 1212 ± 1147
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 2011; McKhann et al., 1984
NFL
(CSF)		 ALS
(68)		 5391 ± 4138
pg/mL §		 ELISA;
Other/Not Specified;
In-house
NFL
(CSF)		 CBS
(21)		 1988 ± 1470
pg/mL §		 ELISA;
Other/Not Specified;
In-house
NFL
(CSF)		 CTRL-
CNC
(75)		 763 ± 1047
pg/mL §		 ELISA;
Other/Not Specified;
In-house
NFL
(CSF)		 DLB
(33)		 1936 ± 3703
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 McKeith et al., 2005
NFL
(CSF)		 FTD-
bvFTD
(46)		 2082 ± 1657
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 Rascovsky et al., 2011
NFL
(CSF)		 FTD-
nfvPPA
(20)		 1637 ± 908
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 Gorno-Tempini et al., 2011
NFL
(CSF)		 FTD-
svPPA
(18)		 2276 ± 1418
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 Gorno-Tempini et al., 2011
NFL
(CSF)		 PD
(41)		 1069 ± 1881
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 Hughes et al., 1992
NFL
(CSF)		 PDD
(29)		 1294 ± 955
pg/mL §		 ELISA;
Other/Not Specified;
In-house
NFL
(CSF)		 PSP
(20)		 2303 ± 1473
pg/mL §		 ELISA;
Other/Not Specified;
In-house
neurogranin
(CSF)		 AD
(397)		 253 ± 187
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 2011; McKhann et al., 1984
neurogranin
(CSF)		 PD
(41)		 140 ± 114
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 Hughes et al., 1992
tau-p181
(CSF)		 AD
(397)		 43 ± 28
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 McKhann et al., 2011; McKhann et al., 1984
tau-p181
(CSF)		 PD
(41)		 20 ± 8
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 Hughes et al., 1992
tau-total
(CSF)		 AD
(397)		 123 ± 76
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 McKhann et al., 2011; McKhann et al., 1984
tau-total
(CSF)		 PD
(41)		 44 ± 19
pg/mL §		 xMAP;
INNOBIA AlzBio3;
Fujirebio		 Hughes et al., 1992

§ Data supplied to Alzforum by author

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This paper appears in the following:

News

  1. Neurofilament Light: A Universal Mark of Neurodegeneration

AlzBiomarker

  1. PD vs AD : Aβ42 (CSF)
  2. AD vs CTRL : NFL (CSF)
  3. ALS vs AD : NFL (CSF)
  4. CBS vs AD : NFL (CSF)
  5. CTRL vs AD : NFL (CSF)
  6. DLB vs AD : NFL (CSF)
  7. FTD vs AD : NFL (CSF)
  8. PDD vs AD : NFL (CSF)
  9. PD vs AD : NFL (CSF)
  10. PSP vs AD : NFL (CSF)
  11. PD vs AD : neurogranin (CSF)
  12. PD vs AD : tau-p181 (CSF)
  13. PD vs AD : tau-total (CSF)