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Jayadevappa R, Chhatre S, Malkowicz SB, Parikh RB, Guzzo T, Wein AJ. Association Between Androgen Deprivation Therapy Use and Diagnosis of Dementia in Men With Prostate Cancer. JAMA Netw Open. 2019 Jul 3;2(7):e196562. PubMed.
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Loughborough University
This is a very interesting study because of its size. It confirms earlier work, in which testosterone deficiency has been associated with Alzheimer’s disease.
The men who received androgen-deprivation therapy were older, less likely to be married, and poorer, all risk factors for Alzheimer’s. However, also in analyses that adjusted for this, the risk with ADT was about 14-24 percent higher.
At Oxford, we found that men with Alzheimer’s had lower levels of testosterone than controls. Testosterone can have multiple protective effects on the brain. A group lead by Christian Pike also found lower levels of brain testosterone in Alzheimer’s. Other studies have shown that ADT is associated with decreases in cognitive function.
However, ADT can help slow the speed of growth of cancer cells in prostate cancer and help control it. Whether the length of time ADT is given should be reviewed based on these and other data may be considered by an expert panel to adjust ADT guidelines.
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