Koistinaho M, Lin S, Wu X, Esterman M, Koger D, Hanson J, Higgs R, Liu F, Malkani S, Bales KR, Paul SM. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nat Med. 2004 Jul;10(7):719-26. PubMed.

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  1. It would be interesting and probably very important to examine whether astrocytes derived from kock-in mice carrying ApoE2, E3, and E4 show any difference in Abeta degradation via exocytosis.

    View all comments by Takaomi Saido

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