Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol. 2010 Jan;67(1):122-31. PubMed.

Recommends

Please login to recommend the paper.

Comments

No Available Comments

Make a Comment

To make a comment you must login or register.

This paper appears in the following:

News

  1. A Foreshadowing? ApoE4 Disrupts Brain Connectivity in Absence of Aβ
  2. Toronto: Human Amyloid Imaging Conference Showcases a Maturing Field
  3. ApoE Disrupts Brain Networks, Helps Microglia Clear Aβ
  4. St. Louis: ApoE—A Clearer View of its Role In AD?
  5. ApoE2 Carriers Have Less Brain Atrophy, AD Pathology in Spinal Fluid
  6. Not All Bad? APOE4 Sharpens Memory in Older People

Mutations

  1. APOE R176C (ApoE2)

Research Timeline Event

  1. ApoE4 genotype influences timing and amount of amyloid deposition in human brain
  2. Prevalence of plaques precedes prevalence of AD dementia by 15 years, starting earlier in ApoE4 carriers