Paradise V, Sabu M, Bafia J, Sharif NA, Nguyen C, DhanrajMukim R, Wang X, Fu J, Ndubisi J, Maldonado G, Strickland M, Figueroa H, Almeida DL, Hyman BT, Holtzman DM, Nuriel T, Ramachandran KV. ApoE isoforms differentially regulate neuronal membrane proteasomes to shift the threshold for pathological aggregation of endogenous Tau. 2022 Nov 29 10.1101/2022.11.29.518293 (version 1) bioRxiv.

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Mutations

  1. APOE C130R (ApoE4)