Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug;14(8):837-42. PubMed.

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  1. After plaques, protofibrils, Aβ42, it is suggested that the killer is the dimer. How can we reconcile this in vitro finding with neuropathological observations of non-demented patients with widespread and huge Aβ aggregates (not plaque cores) in the neocortex?

    View all comments by Andre Delacourte

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