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- Benjamin Wolozin
  Boston University School of Medicine
- Posted: 21 May 2002
BACE is thought to be a potentially important target for therapeutic intervention in AD. BACE1 knockouts appear to be healthy, which suggests that inhibiting BACE might be therapeutically viable. An essential step in predicting any potential toxicity that might be associated with BACE inhibition is identifying its substrates. This paper is important because it has identified the first substrate for BACE other than APP.

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