Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO Mol Med. 2017 Oct;9(10):1356-1365. PubMed.

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This paper appears in the following:

News

  1. TREM2 Cleavage Site Pinpointed: A Gateway to New Therapies?

Mutations

  1. TREM2 H157Y

Research Models

  1. Trem2-H157Y knock-in
  2. TREM2-sol
  3. TREM2-IPD
  4. Trem2-IPDxAPP23xPS45
  5. Trem2-H157Y x 5xFAD