Ancolio K, Marambaud P, Dauch P, Checler F.
Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.
J Neurochem. 1997 Dec;69(6):2494-9.
PubMed.
It is important to understand amyloid production as it relates to presenilin function and apolipoprotein E. The current hypothesis to emphasize Abeta1-42(43) is not enough and should be examined more using in vivo materials such as brain tissues.
Comments
Osaka City University Medical School
This is the first document to the effect of PS-1 mutation on alpha-secretase.
Osaka City University Medical School
It is important to understand amyloid production as it relates to presenilin function and apolipoprotein E. The current hypothesis to emphasize Abeta1-42(43) is not enough and should be examined more using in vivo materials such as brain tissues.
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