Salehi A, Dubelaar EJ, Mulder M, Swaab DF.
Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type dependent.
Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11445-9.
PubMed.
The abstract states "Our data show that the decreased activity of nucleus basalis neurons in AD is ApoE epsilon 4 dependent and suggest that ApoE epsilon 4 participates in the pathogenesis of AD by decreasing neuronal metabolism." Neuronal metabolism is inferred by the size of the Golgi apparatus. When extended to other brain regions, these findings may provide an alternate explanation for the relation between Apo E genotype and when AD appears.
Comments
Banner Research Institute
The abstract states "Our data show that the decreased activity of nucleus basalis neurons in AD is ApoE epsilon 4 dependent and suggest that ApoE epsilon 4 participates in the pathogenesis of AD by decreasing neuronal metabolism." Neuronal metabolism is inferred by the size of the Golgi apparatus. When extended to other brain regions, these findings may provide an alternate explanation for the relation between Apo E genotype and when AD appears.
Make a Comment
To make a comment you must login or register.