Kaspar BK, Vissel B, Bengoechea T, Crone S, Randolph-Moore L, Muller R, Brandon EP, Schaffer D, Verma IM, Lee KF, Heinemann SF, Gage FH. Adeno-associated virus effectively mediates conditional gene modification in the brain. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2320-5. PubMed.

Recommends

Please login to recommend the paper.

Comments

  1. I think this is a good paper, and it adds to our transgenic toolbelt. It may,
    for example, allow us to turn pathology and off, to see if lesions such as
    plaques can be resolved once the source (e.g., elevated Aβ from an AβPP or
    PS1 transgene) is removed. Inducible transgenics have great advantages over
    constitutive ones, although there are also problems associated with the use
    of viral vectors. To be useful, though, it is important that new
    transgenic models in general be made with 'floxed' transgenes so that cre-directed control of transgene expression can be applied without having to make new mice.

    View all comments by Karen Duff

Make a Comment

To make a comment you must login or register.

This paper appears in the following:

News

  1. Adenovirus-Mediated Local Modification of Brain Genotype