Dessi F, Colle MA, Hauw JJ, Duyckaerts C.
Accumulation of SNAP-25 immunoreactive material in axons of Alzheimer's disease.
Neuroreport. 1997 Dec 1;8(17):3685-9.
PubMed.
The thesis of this paper on the role of synaptic markers as correlates of dementia is provocative. But axoplasmic transfer of SNAP-25 may not be the best marker for AD dementia and its transport may be irrelevant to AD pathology.
Assessment of the status of transport in AD is vitally important, and examination by SNAP-25 IHC is appropriate. However, the abstract suggests that the results obtained by these authors is limited to swollen axons.
Comments
Mount Sinai School of Medicine, NYU
The thesis of this paper on the role of synaptic markers as correlates of dementia is provocative. But axoplasmic transfer of SNAP-25 may not be the best marker for AD dementia and its transport may be irrelevant to AD pathology.
Banner Research Institute
Assessment of the status of transport in AD is vitally important, and examination by SNAP-25 IHC is appropriate. However, the abstract suggests that the results obtained by these authors is limited to swollen axons.
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