Stoppini M, Andreola A, Foresti G, Bellotti V.
Neurodegenerative diseases caused by protein aggregation: a phenomenon at the borderline between molecular evolution and ageing.
Pharmacol Res. 2004 Oct;50(4):419-31.
PubMed.
The abstract suggests that this paper emphasizes that pathological aggregates of selected proteins are a consequence of three dimensional structure. This is certainly true. However, it must be recognized that normal functioning of proteins depends heavily on their three dimensional structure. Additionally, negative consequences of "improper" three dimensional structure need not be limited to the formation of aggregates. One example is the negative effect of misfolding of ubiquitin on the functioning of the proteosome.
Comments
Banner Research Institute
The abstract suggests that this paper emphasizes that pathological aggregates of selected proteins are a consequence of three dimensional structure. This is certainly true. However, it must be recognized that normal functioning of proteins depends heavily on their three dimensional structure. Additionally, negative consequences of "improper" three dimensional structure need not be limited to the formation of aggregates. One example is the negative effect of misfolding of ubiquitin on the functioning of the proteosome.
Make a Comment
To make a comment you must login or register.