Metsaars WP, Hauw JJ, van Welsem ME, Duyckaerts C.
A grading system of Alzheimer disease lesions in neocortical areas.
Neurobiol Aging. 2003 Jul-Aug;24(4):563-72.
PubMed.
This grading explains one important feature of Alzheimer's disease, namely the formation of senile plaques: they appear precisely with the arrival of tau pathology in a given area. Senile plaques are in fact a marker of recently affected brain areas by tau pathology. Note to the reader: Brodmann area 17 is the last neocortical region affected in AD (stage 10 of tau pathology; Braak stage VI). This grading fits well with the mechanisms of spreading of the neurodegenerative process. It does not explain if the initial process of neurodegeneration (tau pathology in the entorhinal cortex during stages 1 and 2) is observed prior or simultaneously to amyloid deposits.
References:
Delacourte A, Sergeant N, Champain D, Wattez A, Maurage CA, Lebert F, Pasquier F, David JP.
Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.
Neurology. 2002 Aug 13;59(3):398-407.
PubMed.
Comments
Inserm
This grading explains one important feature of Alzheimer's disease, namely the formation of senile plaques: they appear precisely with the arrival of tau pathology in a given area. Senile plaques are in fact a marker of recently affected brain areas by tau pathology. Note to the reader: Brodmann area 17 is the last neocortical region affected in AD (stage 10 of tau pathology; Braak stage VI). This grading fits well with the mechanisms of spreading of the neurodegenerative process. It does not explain if the initial process of neurodegeneration (tau pathology in the entorhinal cortex during stages 1 and 2) is observed prior or simultaneously to amyloid deposits.
References:
Delacourte A, Sergeant N, Champain D, Wattez A, Maurage CA, Lebert F, Pasquier F, David JP. Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease. Neurology. 2002 Aug 13;59(3):398-407. PubMed.
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