Koldamova RP, Lefterov IM, Ikonomovic MD, Skoko J, Lefterov PI, Isanski BA, Dekosky ST, Lazo JS. 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. J Biol Chem. 2003 Apr 11;278(15):13244-56. PubMed.

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    • User Profile Image Todd E. Golde
      Goizueta Institute @ Emory Brain Health
    • Posted:

    Another paper suggesting with data that support the notion that changes in cellular cholesterol can influence Abeta production. Mechanistic insight is not provided. Nevertheless these data do further reinforce the complex regulation of APP processing and the role of cholesterol in these processes.

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