Ohkubo N, Lee YD, Morishima A, Terashima T, Kikkawa S, Tohyama M, Sakanaka M, Tanaka J, Maeda N, Vitek MP, Mitsuda N. Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. FASEB J. 2003 Feb;17(2):295-7. PubMed.

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  1. This is a beautiful study aimed at unraveling the connection between ApoE, a prominent risk factor for AD, and intracellular signaling and tau phosphorylation. Immunohistochemistry would have been very useful in the interpretation. Perhaps the authors are working on this?

    View all comments by Inez Vincent

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