Sirkis DW, Aparicio RE, Schekman R. Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment. Mol Biol Cell. 2017 Oct 1;28(20):2723-2733. Epub 2017 Aug 2 PubMed.

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Mutations

  1. TREM2 K186N
  2. TREM2 D134G
  3. TREM2 T66M
  4. TREM2 V126G
  5. TREM2 Y38C
  6. TREM2 D86V