Flood DG, Reaume AG, Dorfman KS, Lin YG, Lang DM, Trusko SP, Savage MJ, Annaert WG, De Strooper B, Siman R, Scott RW. FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction. Neurobiol Aging. 2002 May-Jun;23(3):335-48. PubMed.

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Comments

  1. Lovely study to show that under the right circumstances, overexpression of neither ps1 mutation nor app is required to generate amyloid deposition in brains of transgenic mice. The usual massive overexpression of app required to induce amyloid deposition is likely technique related.

    View all comments by Edward Koo

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