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Comments

  1. This paper provides important information about BACE cleavage. It has been known for a long time that multiple Ab peptides consisting of X-38-42 are generated. This paper begins to look at the mechanism of generation of the X-38-42 peptides, and shows that the site of generation plays a role. This is interesting because it points to the importance of trafficking in Ab generation.

    View all comments by Benjamin Wolozin

  2. Interesting study. A bit surprising since glu11 cleaved Ab is not that abundant in vitro or in vivo. Or, maybe we just haven't looked at the glu11 enough?

    View all comments by Edward Koo

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