von Bergen M, Friedhoff P, Biernat J, Heberle J, Mandelkow EM, Mandelkow E. Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34. PubMed.

Recommends

Please login to recommend the paper.

Comments

No Available Comments

Make a Comment

To make a comment you must login or register.

This paper appears in the following:

News

  1. Keystone: Tau, Huntingtin—Do Prion-like Properties Play a Role in Disease?
  2. Structure-Based Approach Yields Tau Inhibitors
  3. Tau Biomarkers—More Informative Fragments in Spinal Fluid?
  4. Monomeric Seeds and Oligomeric Clouds—Proteopathy News from AAIC
  5. From New Tau Structure, Bona Fide Aggregation Inhibitors?
  6. Mounting Modifications Move Tau Toward Aggregation in Alzheimer’s Brain
  7. Aiming at the Tangle’s Heart? DIAN-TU Trial to Torpedo Tau’s Core
  8. New Arrows Aimed at Tau: Single-Domain Antibody, Peptibody, Vaccine
  9. Could an RNA-Binding Protein Prevent Tau Aggregation?

Research Timeline Event

  1. Structural studies find hexapeptides by which tau aggregates into paired helical filaments