Ulery PG, Beers J, Mikhailenko I, Tanzi RE, Rebeck GW, Hyman BT, Strickland DK. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem. 2000 Mar 10;275(10):7410-5. PubMed.

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- Hiroshi Mori
  Osaka City University Medical School
- Posted: 21 May 2002
It is very interesting and desiralbe to enhance the present study because cerebral LRP blockade may be a new anti-AD therapy.

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- Nikolaos K. Robakis
  Mount Sinai School of Medicine, NYU
- Posted: 21 May 2002
This is a very interesting report. As suggested by the authors, it could lead to the discovery of pharmacological agents that decrease amyloid production by acting on LRP.

View all comments by Nikolaos K. Robakis

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