Chiasseu M, Cueva Vargas JL, Destroismaisons L, Vande Velde C, Leclerc N, Di Polo A. Tau Accumulation, Altered Phosphorylation, and Missorting Promote Neurodegeneration in Glaucoma. J Neurosci. 2016 May 25;36(21):5785-98. PubMed.
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Ludwig-Maximilians-Universität Munich
This is a nice paper on retinal pathology in glaucoma that convincingly indicates that phosphorylated tau is critically involved in neurodegeneration in the retina. Targeted tau siRNA led to striking protection of ocular hypertension-induced neuronal damage. This finding does contradict somewhat our study in a transgenic tau mouse model. We did not see a loss of RGCs that accumulated aggregated tau in high amounts (Schön et al., 2012). But analyzing the loss of endogenous tau, as in the present study, is a very different approach from examining the overexpression of mutant human tau that forms fibrillary tau aggregates in mouse RGCs.
References:
Schön C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Steinbach S, Seeliger MW, Arzberger T, Goedert M, Kretzschmar HA, Schmidt B, Herms J. Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. PLoS One. 2012;7(12):e53547. PubMed.
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