Antibody

Anti-PBR antibody (EPR5384)

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Clonality: monoclonal
Host: Rabbit
Isotype: IgG
Source: Abcam
Catalog #: ab109497
Formulation: Tissue culture supernatant. PBS 49 percent, sodium azide 0.01 percent, glycerol 50 percent, BSA 0.05 percent.
Reactivity:
Reacts in: Human, Mouse
Availability: Confirmed available December 2014.

Immunogen/Epitope

A synthetic peptide corresponding to residues at the C-terminus of human peripheral benzodiazepine receptor (PBR)/translocator protein (TSPO).

Specificity

This antibody recognizes PBR, also known as TSPO, a mitochondrial transporter that is upregulated in activated microglia.

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References

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Further Reading

Papers

  1. Buckman LB, Anderson-Baucum EK, Hasty AH, Ellacott KL. Regulation of S100B in white adipose tissue by obesity in mice. Adipocyte. 2014 Jul 1;3(3):215-20. Epub 2014 Apr 4 PubMed.
  2. Faccenda D, Tan CH, Seraphim A, Duchen MR, Campanella M. IF1 limits the apoptotic-signalling cascade by preventing mitochondrial remodelling. Cell Death Differ. 2013 May;20(5):686-97. Epub 2013 Jan 25 PubMed.
  3. Morohaku K, Phuong NS, Selvaraj V. Developmental expression of translocator protein/peripheral benzodiazepine receptor in reproductive tissues. PLoS One. 2013;8(9):e74509. Epub 2013 Sep 5 PubMed.
  4. Thompson MM, Manning HC, Ellacott KL. Translocator protein 18 kDa (TSPO) is regulated in white and brown adipose tissue by obesity. PLoS One. 2013;8(11):e79980. Epub 2013 Nov 18 PubMed.
  5. Karlstetter M, Nothdurfter C, Aslanidis A, Moeller K, Horn F, Scholz R, Neumann H, Weber BH, Rupprecht R, Langmann T. Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. J Neuroinflammation. 2014 Jan 8;11:3. PubMed.
  6. Wang M, Wang X, Zhao L, Ma W, Rodriguez IR, Fariss RN, Wong WT. Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina. J Neurosci. 2014 Mar 5;34(10):3793-806. PubMed.