Systems biology will impact every area of biology and drug development. The tools that now exist to study pathways and systems information are being brought to bear on the complexity of biology for drug discovery. The very nature of systems biology requires integrating data from a variety of sources generated and interpreted by people skilled in different areas, such as engineering, computer science, biology, physics, mathematics, and statistics. Key considerations in this process include the generation of quantitative data, barriers in communication across departments, and organizational challenges. This meeting will address the current challenges and propose solutions, as well as present case studies where a systems biology approach has been implemented successfully.