Antibody

APP (4B4)

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Clonality: monoclonal
Host: Rat
Isotype: IgG2a
Source: (Stefan Lichtenthaler, Adolf Butenandt Institute, Ludwig Maximilians University, München, Germany)
Paper
Reference:
Kuhn, 2010
Reactivity:
Reacts in: Human
<em>not</em> mouse

Immunogen/Epitope

immunogen = a peptide comprising amino acids 11–16 of the Aβ
sequence (EVHHQK-COOH)

Specificity

specifically detects APPsα ending in amino acids 15 and 16 (APPs-15 and APPs-16), but does not detect shorter APPs species, including APPsβ' and APPsβ; does not detect full-length APP

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References

Paper Citations

  1. Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S, Lichtenthaler SF. ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J. 2010 Sep 1;29(17):3020-32. PubMed.

External Citations

  1. Stefan Lichtenthaler
  2. Paper

Further Reading

No Available Further Reading