Antibody

α-synuclein phos Ser129 (pSyn64)

Tools

Back to the Top

Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Wako Chemicals
Cat# 014-20281
References:
Machiya, 2010
Paleologou, 2010
Ihara, 2007
Reactivity:
Reacts in: Rodent (various), Human

Immunogen/Epitope

immunogen = polypeptide (aa 124-134) including phosphorylated Ser129 of human alpha-Synuclein

Specificity

human alpha-Synuclein including phospho. Ser129; does not cross react with normal human alpha-Synuclein

Comments / Questions

No Available Comments

Make a comment or submit a question

To make a comment you must login or register.

References

Paper Citations

  1. Machiya Y, Hara S, Arawaka S, Fukushima S, Sato H, Sakamoto M, Koyama S, Kato T. Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner. J Biol Chem. 2010 Dec 24;285(52):40732-44. PubMed.
  2. Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, Lashuel HA. Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci. 2010 Mar 3;30(9):3184-98. PubMed.
  3. Ihara M, Yamasaki N, Hagiwara A, Tanigaki A, Kitano A, Hikawa R, Tomimoto H, Noda M, Takanashi M, Mori H, Hattori N, Miyakawa T, Kinoshita M. Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron. 2007 Feb 15;53(4):519-33. PubMed.

Further Reading

No Available Further Reading