Clonality: polyclonal
Host: Rabbit
Source: Cell Signaling
Cat# 2451
References:
Ding, 2008
Rockenstein, 2007
No longer available
Formulation: HEPES, NaCl, BSA, glycerol, Protein-A
Reactivity:
Reacts in: Human, Mouse, Rat

Immunogen/Epitope

immunogen = synthetic peptide corresp. to residues surrounding Thr668 of human APP695, conj. to KLH

Specificity

APP A4 when phosphorylated at Thr668 (position corresponding to APP695 isoform)

Comments / Questions

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References

Paper Citations

1. Ding Y, Qiao A, Wang Z, Goodwin JS, Lee ES, Block ML, Allsbrook M, McDonald MP, Fan GH. Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. J Neurosci. 2008 Nov 5;28(45):11622-34. PubMed.
2. Rockenstein E, Torrance M, Adame A, Mante M, Bar-On P, Rose JB, Crews L, Masliah E. Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci. 2007 Feb 21;27(8):1981-91. PubMed.

Further Reading