Antibody

Notch-1, cleaved Val1744 (D3B8)

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Clonality: monoclonal
Host: Rabbit
Isotype: IgG
Source: Cell Signaling
Cat# 4147
Reference (unspecified clonality):
Zhao, 2010
Formulation: liquid, HEPES, BSA, glycerol, saline, azide
Reactivity:
Reacts in: Human, Rat
expect mouse

Immunogen/Epitope

Immunogen = a synthetic peptide corresponding to the sequence at the Val1744 cleavage site of human Notch1

Specificity

detects endogenous levels of the cytosolic domain of Notch1 only when cleaved between Gly1743 and Val1744; does not recognize full length Notch1 or Notch1 cleaved at other positions

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References

Paper Citations

  1. Zhao G, Liu Z, Ilagan MX, Kopan R. Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J Neurosci. 2010 Feb 3;30(5):1648-56. PubMed.

Further Reading

No Available Further Reading