Jobs
Postdoctoral Researcher
Posted 01 Nov 2024
Employer
University of Leuven and VIB
Principal Investigator
Contact
Description
The postdoctoral scientist will join the multidisciplinary project on gene therapy for Alzheimer’s disease. This work is focused on the specific targeting of clinical mutations that cause dominant inherited Alzheimer’s disease using a unique antisense strategy (ASO). The group will couple those ASO to their proprietary blood-brain shuttles to improve brain exposure, improve administration via intravenous instead of intrathecal routes, and decrease toxicity associated with ASO treatment.
The candidate will be involved in both the generation and the testing of the ASO constructs and will follow the clinical candidates on their journey from preclinical to clinical application.
Requirements
Should hold a Ph.D. degree in neuroscience, biology, chemistry, engineering or a related field. Should be creative, enthusiastic, critically thinking, and motivated. Ready to work against stringent deadlines. Enjoys teamwork and has excellent oral and written communication skills in English.
Appreciated
Experience working with laboratory mice (FELASA B). Project management and effective communication skills. Knowledge of the literature on neurodegenerative disorders. Good understanding of antisense oligonucleotide therapies. Interested in brain delivery of drugs. Good publication record.