Pappolla MA, Refolo L, Sambamurti K, Zambon D, Duff K. Hypercholesterolemia and Alzheimer's Disease: Unraveling the Connection and Assessing the Efficacy of Lipid-Lowering Therapies. J Alzheimers Dis. 2024;101(s1):S371-S393. PubMed.
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Mount Sinai School of Medicine, NYU
This review article on hypercholesterolemia and Alzheimer's disease is an excellent contribution to understanding the complex link between cholesterol management and AD pathology, providing valuable insights for both clinicians and researchers.
Here are a few highlights of the paper: It explores mechanistic relationships between cholesterol and amyloid deposition and includes a discussion of studies on transgenic mouse models and human autopsy findings. This strengthens the theoretical basis for therapeutic interventions. It also offers a balanced review of empirical studies and clinical trials examining the effects of statins on AD risk. By analyzing age-related dynamics, statin type, and patient characteristics, the authors shed light on why clinical trials failed to consistently show protective effects and suggest areas for future improvements in clinical trial designs.
In summary, the article may serve as a comprehensive guide for clinicians and researchers as it illuminates the importance of cholesterol in AD and open new avenues for therapeutic exploration.
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