Antibody

Amyloid-β (N-terminal) (82E1)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: DEMEDITEC Diagnostics GmbH
Catalog #: 10323
Formulation: liquid, supernatant, affinity purified
Reactivity:
Reacts in: Human
does not cross react with mouse or rat

Immunogen/Epitope

immunogen = human Amyloid β

Specificity

Amyloid β N-terminal specific; reacts with both soluble and fibrillar Aβ to a similar degree; no cross reaction with holo-APP

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Further Reading

Papers

  1. Wakabayashi T, Craessaerts K, Bammens L, Bentahir M, Borgions F, Herdewijn P, Staes A, Timmerman E, Vandekerckhove J, Rubinstein E, Boucheix C, Gevaert K, De Strooper B. Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat Cell Biol. 2009 Nov;11(11):1340-6. PubMed.
  2. Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science. 2009 May 1;324(5927):639-42. Epub 2009 Mar 19 PubMed.