Antibody

Tau (TAU-5)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Source: Lab Vision Thermo Scientific
Cat# MS-247
References:
Adams, 2009
Yuzawa, 2008
Formulation: ascites, protein-G, PBS, with or w/o BSA and azide, and as Biotin conj.
Reactivity:
Reacts in: Cow, Sheep, Human, Mouse, Rat

Immunogen/Epitope

immunogen = bovine MAPs (epitope sequence in the middle of tau)

Specificity

45-68 kDa tau, phos. or non-phos., in neurofibrillary tangles, neuropil threads, neuritic plaques, astrocytes and ribosomes, not other MAPs or tubulin

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References

Paper Citations

  1. Adams SJ, Crook RJ, Deture M, Randle SJ, Innes AE, Yu XZ, Lin WL, Dugger BN, McBride M, Hutton M, Dickson DW, McGowan E. Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. Am J Pathol. 2009 Oct;175(4):1598-609. PubMed.
  2. Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat Chem Biol. 2008 Aug;4(8):483-90. PubMed.

Further Reading

No Available Further Reading