Jobs

Postdoctoral fellow in Alzheimer’s Disease functional genomics by computational approaches

Posted 06 Mar 2024

Employer

Boston University

Location

Boston , Massachusetts

Principal Investigator

Julia TCW

Contact

• Interested candidates should submit a cover letter outlining their research interests and career goals, a current CV, and contact information for three references to Dr. Julia TCW, Assistant professor and Director [juliatcw@bu.edu] or https://sites.bu.edu/tcwlab/talent-aquisition/.
• Review of applications will begin immediately and continue until the position is filled.

Description

The TCW laboratory in the Department of Pharmacology, Physiology & Biophysics at Boston University Chobanian & Avedisian School of Medicine in Boston is looking for highly motivated and skilled computational geneticist, bioinformatician, statistician to be the drivers of our efforts to translate the genetics of Alzheimer’s disease (AD) toward therapeutic interventions. 

The core program is to better characterize the effect of the AD variants on molecular phenotypes by functional genetics and multiomics approaches. As a part of Functional Genomics Consortium (xQTL study) in Alzheimer’s Disease Sequencing Project (ADSP), we are focus on methylation QTL and integrate it with other omics data (transcriptomics, proteomics, and metabolomics) to decipher the genome-wide molecular pathways associated with AD risk. The TCW lab analyzed the transcriptomics and chromatin accessibility in each cell type using brain organoids from patient AD iPSCs and single cell multi-omics approach. The candidate will join a multidisciplinary and highly collaborative research team that includes computational geneticists, neuroscientists and pharmacologists in the department as well as Genome Science Institute and Center for Systems Neuroscience at Boston University.

Benefits

• Competitive salary commensurate with benefits.
• Access to state-of-the-art computational resources and laboratory facilities.
• Opportunities for professional development, including attending conferences and workshops.
• Collaborative and stimulating research environment with mentorship from experienced scientists and experimental wet lab.
• Potential for career advancement and transition to independent research positions.

About TCW Lab

The TCW lab is dedicated to advancing understanding of neurodegenerative diseases and aging, with a particular focus on Alzheimer's disease. It utilizes cutting-edge biotechnologies, computational and interdisciplinary approaches to dissect the molecular pathways underlying genetic susceptibilities and disease pathogenesis and identify novel therapeutic targets. As a member of the team, you will have the opportunity to collaborate with leading experts in the field and contribute to impactful research that has the potential to improve the lives of patients affected by Alzheimer's disease.

The lab is committed to fostering a diverse and inclusive research environment and encourage applications from individuals of all backgrounds.

Requirements

Qualifications

• Ph.D. in computational biology, bioinformatics, genetics, data science, computational neuroscience, or a related field
• Proficiency in programming languages, particularly R, bash, and Python, for data analysis and visualization

Preferred skill sets

• Experience in analyzing large-scale genomic and transcriptomic datasets
• Or, strong background in statistical methods and machine learning techniques 
• Or, analysis of any of large-scale genomic datasets (RNA-Seq, ChIP-Seq, ATAC-Seq, Hi-C)
• Or, single-cell multiomic data analysis (ATAC-seq, RNA-seq, proteomics/metabolomics)
• Clear written and oral communication and detailed documentation skills, with the ability to collaborate effectively across disciplines