Research Models
Sorl1*A528T
Species: Mouse
Genes: Sorl1
Mutations: SORL1 A528T (SNP 13)
Modification: Sorl1: Knock-In
Disease Relevance: Alzheimer's Disease
Strain Name: B6.Cg-Sorl1em1Adiuj/J
Genetic Background: C57BL/6J
Availability: Available from The Jackson Laboratory, JAX Stock# 032759; cryorecovery.
A528T is a common variant of SORL1 that has been shown to associate with a slightly increased risk of AD (~15 percent) in people of European ancestry and to segregate with disease in some families. CRISPR/Cas9 gene editing was used to introduce the A528T missense mutation into the mouse Sorl1 gene.
Heterozygous and homozygous mice are viable and fertile.
Modification Details
CRISPR/Cas9 gene editing was used to introduce the A528T missense mutation and a silent mutation (R529R) into the mouse Sorl1 gene in APOE4/Trem2*R47H mice (JAX 028709). Correctly targeted mice were then backcrossed to C57BL/6J mice (JAX 000664) to remove the human APOE4 sequence and the Trem2 mutation.
Phenotype Characterization
When visualized, these models will distributed over a 18 month timeline demarcated at the following intervals: 1mo, 3mo, 6mo, 9mo, 12mo, 15mo, 18mo+.
Absent
No Data
- Plaques
- Tangles
- Neuronal Loss
- Gliosis
- Synaptic Loss
- Changes in LTP/LTD
- Cognitive Impairment
Plaques
No data.
Tangles
No data.
Neuronal Loss
No data.
Gliosis
No data.
Synaptic Loss
No data.
Changes in LTP/LTD
No data.
Cognitive Impairment
No data.
Last Updated: 18 Sep 2023
References
Mutations Citations
Research Models Citations
External Citations
Further Reading
No Available Further Reading
COMMENTS / QUESTIONS
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