Epigenetics/epigenomics is an emerging field of science that involves the study of changes in the regulation of gene activity and expression that are not dependent on gene sequence. One of the major take home messages from a recent NIA workshop entitled “Epigenetics of Aging and Age-related Diseases” was that an integrated genetic-epigenetic approach holds great promise for understanding the etiology of complex diseases of aging. With this in mind and in order to further leverage the Roadmap investment in epigenomics and maximize NIA's investment in the genetics of Alzheimer’s disease (AD), the Division of Neuroscience, NIA, will convene an exploratory workshop in Bethesda, MD on June 7-8, 2010, that will bring together AD Genetics Consortium (ADGC) investigators funded through the Roadmap Epigenomics RFA, other leading epigenomics experts working on related diseases and conditions, and NIA’s leading geneticists involved in the major AD genetics initiatives such as LOAD (Late Onset AD Family study). The purpose of this workshop is to explore synergies between these two approaches and to facilitate interactions between leading experts in AD genetics and leading epigenomics experts, and to review the current state of AD genetics and the emerging epigenetic approach to AD.