Alzpedia
Leucine-rich repeat kinase 2 (LRRK2)
Synonyms: PARK8, dardarin
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News
- PARK8 is Cloned: Introducing…"Dardarin"
- Not Just a Family Affair: Dardarin Mutations Predict Sporadic PD
- More Than a LRRK: PD Field Thinks Big With Genetic Cohort
- Evidence Piles Up for Lysosomal Dysfunction in Parkinson’s
- New Substrate for Parkinson’s Protein Is Picky About Phosphate
- The Many Faces of LRRK2
- LRRK Watchers’ Eyes Turn to Inflammation, Autophagy, Kinase
- Rethinking LRRK2 Toxicity: It’s How Much Is Present, Not What It Does
- LRRK2 Interactions Identify New Parkinson’s Genes, Implicate Autophagy
Papers
- Hyun CH, Yoon CY, Lee HJ, Lee SJ. LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's Disease. Exp Neurobiol. 2013 Dec;22(4):249-57. Epub 2013 Dec 31 PubMed.
- Chan SL, Angeles DC, Tan EK. Targeting leucine-rich repeat kinase 2 in Parkinson's disease. Expert Opin Ther Targets. 2013 Dec;17(12):1471-82. Epub 2013 Nov 9 PubMed.
- Tsika E, Moore DJ. Contribution of GTPase activity to LRRK2-associated Parkinson disease. Small GTPases. 2013 Jul-Sep;4(3):164-70. Epub 2013 Jun 10 PubMed.
- Rideout HJ, Stefanis L. The Neurobiology of LRRK2 and its Role in the Pathogenesis of Parkinson's Disease. Neurochem Res. 2013 Jun 1; PubMed.
- Dzamko N, Halliday GM. An emerging role for LRRK2 in the immune system. Biochem Soc Trans. 2012 Oct;40(5):1134-9. PubMed.
- Sloan M, Alegre-Abarrategui J, Wade-Martins R. Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models. Biochem Soc Trans. 2012 Oct;40(5):1080-5. PubMed.