Research Models
Tg-mAPP/DN-RAGE
Synonyms: mAPP/DN-RAGE, APP/DN-RAGE
Species: Mouse
Genes: APP, RAGE (AGER)
Mutations: APP K670_M671delinsNL (Swedish), APP V717F (Indiana)
Modification: APP: Transgenic; RAGE (AGER): Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: C57BL/6
Availability: Available through Shirley ShiDu Yan
Neuropathology
Bigenic mice expressing dominant-negative RAGE as well as mutant APP displayed diminished neuropathology compared with mice expressing mutant APP alone, including the area occupied by acetylcholinesterase-positive fibers in the subiculum at three to four and 14 to 18 months of age (Arancio et al., 2004).
Cognition/Behavior
Bigenic mice displayed preservation of spatial learning and memory compared with Tg-mAPP/RAGE animals (Arancio et al., 2004).
Other Phenotypes
No abnormalities were reported with respect to reproductive fitness, development, basic neurological functioning, or longevity (Arancio et al., 2004).
Modification Details
Mice expressing a dominant-negative form of RAGE comprising a truncated form of the receptor with intact extracellular and membrane-spanning portions, but a deleted cytosolic tail driven by the PDGF-β promoter were crossed with mice expressing human APP carrying the Swedish and Indiana mutations driven by PDGF-β promoter (The Jackson Lab: Stock# 004661--now extinct).
Last Updated: 06 Mar 2018
References
Research Models Citations
Paper Citations
- Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Du Yan SS. RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. EMBO J. 2004 Oct 13;23(20):4096-105. PubMed.
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