This manuscript complements, in a very good way, work we recently published (Talantova et al., 2013),describing for first time the important role of astrocytic α7-nAChRs in Aβ amyloid calcium dysregulation and toxicity.
References:
Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA.
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.
Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2518-27.
PubMed.
Comments
This manuscript complements, in a very good way, work we recently published (Talantova et al., 2013),describing for first time the important role of astrocytic α7-nAChRs in Aβ amyloid calcium dysregulation and toxicity.
References:
Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2518-27. PubMed.
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