AlzBiomarker
Creutzfeldt-Jakob Disease (Genetic) vs Alzheimer's Disease: NFL (CSF)
In our meta-analysis of two studies, the level of neurofilament light chain in the cerebrospinal fluid of people with genetically-determined Creutzfeldt-Jakob disease (caused by the E200K mutation in PRNP) appeared to be double that of people with Alzheimer's disease (effect size = 2.002, p = 0.039). However, the p value was of marginal signficance, and one study showed higher levels of NFL in gCJD than in AD, while the other study showed lower levels. For comparison, our meta-analysis showed a five-fold increase in CSF NFL in people with sporadic Creutzfeldt-Jakob disease compared with AD patients. A meta-analysis comparing CJD patients —without specifying etiology—to control subjects found a 10-fold increase in the levels of NFL in the CSF of patients (Wang et al., 2017).
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