Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth HU, Rossner S. Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med. 2008 Oct;14(10):1106-11. Epub 2008 Sep 28 PubMed.
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Comments
This seems to be a very interesting and consistent hypothesis opening exciting avenues for drug development. Potentially a breakthrough. Has it been possible to reconcile the data with the reference below?
References:
Tekirian TL, Yang AY, Glabe C, Geddes JW. Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42. J Neurochem. 1999 Oct;73(4):1584-9. PubMed.
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