Berger-Sweeney J, McPhie DL, Arters JA, Greenan J, Oster-Granite ML, Neve RL. Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein. Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):150-62. PubMed.
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Osaka City University Medical School
APP C-100 Tg mouse is interesting because of its neuronal loss in the brain and impairment of learning as compared with other Tg mice. This article shows that abnormality of this mouse is somewhat gender and age-dependent.
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