Blackmore DG, Turpin F, Palliyaguru T, Evans HT, Chicoteau A, Lee W, Pelekanos M, Nguyen N, Song J, Sullivan RK, Sah P, Bartlett PF, Götz J. Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling. Mol Psychiatry. 2021 May 27; PubMed.

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  1. Blackmore et al. is another exciting paper from the Götz group, building on their success with low-intensity ultrasound. They show powerful activation of the hippocampal circuitry, manifested by enhanced plasticity and memory restoration. This treatment increased hippocampal neurogenesis, upregulated synaptic proteins, improved synaptic receptor function, and restored LTP induction in senescent mice.

    The scanning ultrasound (SUS) is an intriguing approach that seems to have a profound effect on neural function. Blackmore et al. speculate that SUS may cause the opening of TRPA1 channels in astrocytes, resulting in the entry of Ca2+ ions. It would be fascinating to learn more about the underlying mechanisms and the concerted effect on astrocytes and neurons that lead to increased plasticity.

    This approach is noninvasive, focal, and capable of targeting subcortical areas. The low energy minimizes the chance of peripheral damage. These qualities should translate well into human therapy. Since it induces transient plasticity, it would be necessary to determine treatment frequency.

    View all comments by Orly Lazarov

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