. Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability. J Neurochem. 1997 Dec;69(6):2452-65. PubMed.

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  1. A different Kd of perlecan with two Abeta species in the binding should provide a mechanism for cofactors to enhance amyloid fibriol formation.

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