Vandermeeren M, Mercken M, Vanmechelen E, Six J, van de Voorde A, Martin JJ, Cras P. Detection of tau proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay. J Neurochem. 1993 Nov;61(5):1828-34. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
tau-total
(CSF)		 AD
(27)		 10.9 ± 4.9
pg/mL		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
Other Controls
(51)		 0.1 ± 0.5
pg/mL		 ELISA;
Other/Not Specified;
In-house

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Research Timeline Event

  1. AD signature found in CSF: tau increased, Aβ42 decreased

AlzBiomarker

  1. AD vs CTRL : tau-total (CSF)
  2. CTRL vs AD : tau-total (CSF)