Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet. 1993 Sep 18;342(8873):697-9. PubMed.

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Mutations

  1. APOE C130R (ApoE4)

Research Timeline Event

  1. ApoE4 major risk factor for late-onset AD; risk up threefold with one allele, 12-fold with two; ApoE2 protective