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Emre M, Tsolaki M, Bonuccelli U, Destée A, Tolosa E, Kutzelnigg A, Ceballos-Baumann A, Zdravkovic S, Bladström A, Jones R, . Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2010 Oct;9(10):969-77. PubMed.
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Western Nevada College
Amyloid-β is likely an intermediate in the development of dementia and neuronal cell death in Alzheimer disease and in some cases of Parkinson disease, whereas peroxynitrites may be the principal culprit. Through oxidation and nitration, peroxynitrites disrupt neurotransmissions and lead to a critical shortage of acetylcholine, which is involved in the retrieval of short-term memories. Polyphenols can be used to scavenge peroxynitrites and to partially reverse both peroxynitrite-mediated oxidation and nitration of proteins. The progression of certain types of dementia may thus not only be stopped, but partially reversed.
References:
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