Spies PE, Melis RJ, Sjögren MJ, Rikkert MG, Verbeek MM. Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders. J Alzheimers Dis. 2009;16(2):363-9. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
α-synuclein
(CSF)		 AD
(131)		 37 ± 36.1
ng/mL		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
α-synuclein
(CSF)		 CTRL-
CNC
(57)		 30.4 ± 19.1
ng/mL		 ELISA;
Other/Not Specified;
In-house
α-synuclein
(CSF)		 DLB
(40)		 38 ± 29
ng/mL		 ELISA;
Other/Not Specified;
In-house		 McKeith et al., 1996
α-synuclein
(CSF)		 FTD
(39)		 49.1 ± 41.5
ng/mL		 ELISA;
Other/Not Specified;
In-house		 Neary et al., 1998

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News

  1. Still Early Days for α-synuclein Fluid Marker

AlzBiomarker

  1. AD vs CTRL : α-synuclein (CSF)
  2. CTRL vs AD : α-synuclein (CSF)
  3. DLB vs AD : α-synuclein (CSF)
  4. FTD vs AD : α-synuclein (CSF)