den Dunnen WF, Brouwer WH, Bijlard E, Kamphuis J, van Linschoten K, Eggens-Meijer E, Holstege G.
No disease in the brain of a 115-year-old woman.
Neurobiol Aging. 2008 Aug;29(8):1127-32.
PubMed.
These results fit well with our brain bank data: hippocampal tangles are always observed in aging, more or less. With amyloidosis, there is a development of the basic tauopathy, leading to Alzheimer disease.
References:
Delacourte A, Sergeant N, Champain D, Wattez A, Maurage CA, Lebert F, Pasquier F, David JP.
Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.
Neurology. 2002 Aug 13;59(3):398-407.
PubMed.
Comments
In addition to this woman's brain, I hope that her eating habits, lifestyle, etc. can be investigated.
View all comments by J. Lucy BoydInserm
These results fit well with our brain bank data: hippocampal tangles are always observed in aging, more or less. With amyloidosis, there is a development of the basic tauopathy, leading to Alzheimer disease.
References:
Delacourte A, Sergeant N, Champain D, Wattez A, Maurage CA, Lebert F, Pasquier F, David JP. Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease. Neurology. 2002 Aug 13;59(3):398-407. PubMed.
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