Uryu K, Chen XH, Martinez D, Browne KD, Johnson VE, Graham DI, Lee VM, Trojanowski JQ, Smith DH.
Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans.
Exp Neurol. 2007 Dec;208(2):185-92.
PubMed.
This is an important and well-done study in human brain tissue providing support for the findings by Larry Goldstein's lab (Kamal et al., 2000; Stokin et al., 2005) that the axon is a site of Aβ production. The data are furthermore consistent with previous findings in animal studies.
References:
Kamal A, Stokin GB, Yang Z, Xia CH, Goldstein LS.
Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.
Neuron. 2000 Nov;28(2):449-59.
PubMed.
Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LS.
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease.
Science. 2005 Feb 25;307(5713):1282-8.
PubMed.
Comments
The University of Queensland
This is an important and well-done study in human brain tissue providing support for the findings by Larry Goldstein's lab (Kamal et al., 2000; Stokin et al., 2005) that the axon is a site of Aβ production. The data are furthermore consistent with previous findings in animal studies.
References:
Kamal A, Stokin GB, Yang Z, Xia CH, Goldstein LS. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron. 2000 Nov;28(2):449-59. PubMed.
Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LS. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005 Feb 25;307(5713):1282-8. PubMed.
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